LOS ANGELES (AP) — Reese Witherspoon, Mahershala Ali and Keith Urban are among the stars joining the sixth Stand Up To Cancer telethon.

Jennifer Garner, Trevor Noah, Marlee Matlin, Matthew McConaughey and organization co-founder Katie Couric also will take part in the Sept. 7 fundraiser.

Stand Up To Cancer said Thursday that this year’s live, hour-long telecast commemorates 10 years of raising awareness and more than $480 million to fund innovative research.

Bradley Cooper is returning as co-executive producer of the event, which will be carried commercial-free by major broadcast networks and cable channels in the U.S. and Canada and on streaming platforms.

In a statement, Cooper noted that his family has been touched by cancer and called it a privilege to be back with the telethon. His father, Charles J. Cooper, had lung cancer and died in 2011.

Others participating in the Stand Up to Cancer broadcast include Kathy Bates, Tony Hale, Marg Helgenberger, Ed Helms, Ken Jeong, Maria Menounos, Jillian Michaels, Dak Prescott, Italia Ricci, Rob Riggle, Karla Souza and David Spade.